Top 15 Iconic Hotels and Getaways in Mississippi (Currently Open)
From the blues-soaked Delta to the serene Gulf Coast, Mississippi offers a remarkable range of destinations that perfectly blend Southern charm, history, and hospitality. Whether you’re looking for a luxurious seaside escape, a romantic bed and breakfast, or a historic hotel filled with stories from the past, the Magnolia State has something unforgettable waiting for every traveler.
This guide showcases the Top 15 Iconic Hotels and Getaways in Mississippi (Currently Open) — each one offering its own unique character, comfort, and connection to Mississippi’s rich culture.
The Alluvian Hotel – Oxford Elegance in Greenwood
Located in the heart of Greenwood, The Alluvian Hotel is one of Mississippi’s crown jewels of hospitality. This elegant boutique hotel captures the essence of Delta sophistication, offering a refined stay for guests who appreciate both luxury and local culture.
What Makes It Iconic:
The hotel is part of the Viking Range Corporation family and directly across from the Viking Cooking School, where guests can take hands-on culinary classes.
Features an upscale spa, art-filled interiors, and a rooftop terrace overlooking downtown Greenwood.
Perfect for couples seeking a romantic getaway or foodies craving an authentic Delta experience.
With its blend of modern comfort and Southern refinement, The Alluvian has become a symbol of Delta revival.
The White House Hotel – Coastal Charm in Biloxi
Perched along the Mississippi Gulf Coast, The White House Hotel combines historic grandeur with coastal relaxation. Originally built in the early 1900s, this restored gem offers panoramic views of the Gulf of Mexico and easy access to Biloxi’s best beaches and casinos.
Why Guests Love It:
Elegant white-columned architecture and a wraparound veranda that radiates Old South romance.
The on-site Cora’s Restaurant serves coastal-inspired cuisine in a stylish, relaxed setting.
Close to top attractions like the Biloxi Lighthouse and Beau Rivage Resort & Casino.
The White House Hotel offers that rare mix of historic charm and modern luxury, making it a favorite for both weekend travelers and wedding parties.
Monmouth Historic Inn – Antebellum Grandeur in Natchez
If you’ve ever dreamed of stepping into a Southern novel, Monmouth Historic Inn in Natchez makes that dream come true. Built in 1818, this National Historic Landmark immerses guests in the elegance of the antebellum era.
Highlights Include:
Lavishly restored rooms with antique furnishings and four-poster beds.
Guided tours of the mansion and its beautifully manicured gardens.
Fine dining at the 1818 Restaurant, known for Southern classics with a gourmet twist.
Monmouth is ideal for history buffs, honeymooners, and anyone seeking timeless Mississippi charm.
The Graduate Oxford – Retro Cool Meets College Town Energy
Located near the University of Mississippi, The Graduate Oxford delivers a colorful, contemporary experience infused with nostalgic touches that celebrate the spirit of Ole Miss.
Why It Stands Out:
Decor inspired by Oxford’s literary and academic history, featuring playful design elements and vintage furnishings.
The Coop Rooftop Bar offers cocktails with stunning views of the Square.
Walkable to Oxford’s legendary bookstores, boutiques, and restaurants.
This hotel perfectly balances Southern tradition and youthful creativity, making it a favorite among visitors exploring Oxford’s lively downtown.
Beau Rivage Resort & Casino – Gulf Coast Luxury at Its Finest
When it comes to luxury resorts in Mississippi, few places rival the Beau Rivage Resort & Casino in Biloxi. Operated by MGM Resorts, this lavish waterfront property delivers Vegas-level entertainment with unmistakable Southern flair.
Signature Features:
Elegant rooms with Gulf views.
A world-class casino, spa, and multiple fine dining options.
Seasonal shows, concerts, and golf at the nearby Fallen Oak Golf Course.
Perfect for those seeking glitz, glamour, and Gulf Coast relaxation, the Beau Rivage defines Mississippi’s high-end getaway experience.
The Roost Boutique Hotel – Artful Escape in Ocean Springs
Tucked away in Ocean Springs, The Roost Boutique Hotel is a serene retreat that combines nature, art, and modern design. This boutique gem sits within walking distance of local art galleries, cafés, and the beach.
Why It’s Beloved:
Stylish suites filled with local artwork and custom furnishings.
Peaceful setting surrounded by ancient live oaks.
The adjacent White Pillars Restaurant offers one of the best dining experiences on the Coast.
For those seeking romance and relaxation, The Roost is a perfect escape that embodies Mississippi’s coastal creativity.
King’s Daughters Bed & Breakfast – Southern Serenity in Brookhaven
In the charming town of Brookhaven, King’s Daughters Bed & Breakfast offers guests a peaceful stay in a beautifully restored 19th-century home. This family-run inn captures everything special about small-town Mississippi.
Top Features:
Individually decorated rooms that reflect historic Southern style.
Homemade breakfasts featuring local ingredients.
A warm, welcoming atmosphere ideal for couples or solo travelers.
It’s the kind of place where you arrive as a guest but leave feeling like family — a true Mississippi gem.
The Inn at Ocean Springs – Coastal Comfort and Artistry
For travelers seeking both beach access and boutique charm, The Inn at Ocean Springs is a standout. Nestled in the heart of downtown, this small but stunning inn captures the city’s coastal elegance.
Why You’ll Love It:
Cozy, stylish rooms within walking distance to Front Beach.
Complimentary bicycles for exploring local attractions.
Surrounded by art galleries, cafés, and live music venues.
Perfect for a romantic weekend getaway, the Inn delivers Mississippi’s signature blend of relaxation and creativity.
The Westin Jackson – Contemporary Comfort in the Capital City
As Jackson’s premier luxury hotel, The Westin Jackson redefines what urban sophistication looks like in the South. Just steps away from the Mississippi Museum of Art and the Capitol Building, it’s the perfect stay for both business and leisure travelers.
Standout Amenities:
Spacious, modern rooms with premium bedding and rainfall showers.
On-site Estelle Wine Bar & Bistro, known for inventive Southern cuisine.
A heated indoor pool, fitness center, and rejuvenating spa.
It’s the ultimate base for exploring Mississippi’s cultural heart while indulging in world-class comfort.
The Shack Up Inn – A Blues Lover’s Dream in Clarksdale
Few places capture the soul of the Mississippi Delta like The Shack Up Inn. Located on the historic Hopson Plantation in Clarksdale, this quirky destination offers a rustic, one-of-a-kind stay surrounded by blues history.
Why It’s Iconic:
Guests stay in restored sharecropper shacks and grain bins.
Frequent live music performances and festivals celebrating Delta blues.
Authentic atmosphere filled with vintage décor and Southern character.
For music enthusiasts, it’s more than a hotel — it’s a pilgrimage to the birthplace of the blues.
Dunleith Historic Inn – Timeless Luxury in Natchez
Dunleith Historic Inn stands as one of the most beautiful and storied properties in Natchez. Built in 1856, this Greek Revival mansion sits on 40 acres of landscaped grounds, transporting guests to another era.
Highlights:
Twelve elegant guest rooms featuring antique furniture and fireplaces.
On-site restaurant and tavern serving upscale Southern dishes.
Guided tours that share the estate’s fascinating history.
Dunleith is perfect for history lovers and romantics looking for an authentic Mississippi experience wrapped in grandeur.
The Threefoot Hotel – Historic Revival in Meridian
Located in downtown Meridian, The Threefoot Hotel brings 1920s glamour into the modern era. Part of the Marriott Tribute Portfolio, this beautifully restored art deco landmark offers a stylish stay in one of Mississippi’s emerging cultural cities.
What to Expect:
Luxurious rooms with period-inspired design.
Boxcar Restaurant featuring Southern-inspired cuisine.
Close to attractions like the Mississippi Arts + Entertainment Experience (The MAX).
It’s a blend of heritage and modern hospitality, proving that small-city Mississippi can shine just as bright as the big destinations.
Hard Rock Hotel & Casino – High-Energy Getaway in Biloxi
For those who like their vacations loud and lively, the Hard Rock Hotel & Casino Biloxi delivers excitement from check-in to checkout.
Highlights Include:
Music-themed rooms with Gulf views.
A buzzing casino, poolside cabanas, and world-class entertainment.
Themed restaurants and bars featuring rock memorabilia from music legends.
This destination is ideal for couples or friends looking for nightlife, luxury, and non-stop fun on the Mississippi Coast.
The Fairview Inn – Historic Comfort in Jackson
The Fairview Inn is one of the most elegant bed and breakfasts in the state, offering a refined stay in a 1908 Colonial Revival mansion. Located in Jackson’s historic Belhaven district, this inn blends modern luxury with classic Mississippi heritage.
Why Stay Here:
Individually styled rooms with antique furnishings.
An award-winning spa and Library Lounge, a favorite for craft cocktails.
Close to cultural landmarks like the Eudora Welty House and Mississippi Museum of Art.
It’s a peaceful urban retreat that captures Jackson’s literary and cultural legacy in style.
The Great Southern Hotel – Timeless Hospitality in Gulfport
In Gulfport, the Great Southern Hotel has stood for over a century as a symbol of enduring hospitality. Though it has undergone modern renovations, it still retains its historic charm.
Guests Appreciate:
Proximity to Gulfport Beach and the marina.
Modern amenities paired with old-fashioned Southern service.
Easy access to restaurants, casinos, and water adventures.
This hotel is an excellent choice for families and couples looking to explore Mississippi’s sparkling Gulf Coast.
Conclusion: Discover the Heart of Southern Hospitality
From the stately mansions of Natchez to the artistic hideaways of Ocean Springs, these iconic hotels and getaways in Mississippi reveal why the Magnolia State remains a timeless destination for travelers who crave both comfort and culture.
Whether you’re drawn by history, luxury, music, or the simple pleasure of Southern hospitality, Mississippi’s hotels offer more than a place to rest—they offer an experience that lingers long after checkout.